ISRAEL has ordered another mass evacuation in southern Gaza, saying its forces will soon operate there in response to Palestinian rocket fire.

Khan Younis, Gaza’s second-largest city, suffered widespread destruction during air and ground operations earlier this year and is braced for more devastation following the evacuation order.

Israeli forces have repeatedly returned to heavily destroyed areas of Gaza where they had fought earlier battles against Hamas and other militants since the start of the 10-month-old war.

Gaza faces a severe humanitarian crisis, with Israeli restrictions on aid and ongoing fighting limiting access to crucial medical, food and other supplies.

READ MORE: Charity pleads for protection of crucial hospital in Gaza

The Health Ministry says the death toll in the territory is nearing 40,000.

Regional tensions have soared since Hamas political leader Ismail Haniyeh was killed in Iran by a presumed Israeli strike on July 31, and retaliation has been expected.

French President Emmanuel Macron urged Iranian President Masoud Pezeshkian in a phone call to do everything in his power to avoid a new military escalation that he said would do lasting damage to regional stability.

World leaders have been pushing for a ceasefire in Gaza, and US President Joe Biden spoke with Egyptian President Abdel Fattah El-Sisi on Tuesday about their hopes for a deal calming tensions in the Middle East.

Israeli Prime Minister Benjamin Netanyahu told his Cabinet over the weekend that Israel is already in a “multi-front war” with Iran and its proxies.